Aim: Endoscopic retrograde cholangiopancreatography has been used primarily for therapeutic interventions. Precut sphincterotomy is a technique that is used after conventional methods of biliary cannulation have failed. We aimed to examine if the precut technique increases the frequency of complications.\nMaterial and Method: Two hundred fifteen patients, on whom endoscopic retrograde cholangiopancreatography (ERCP) was performed, were prospectively evaluated. One hundred eighty-five patients included in the study were divided into three groups based on the cannulation techniques: group 1: deep biliary cannulation or cannulation by guide wire; group 2: precut technique; group 3: If cannulation was not possible with these two techniques within 10 minutes, a precut with needle-knife sphincterotomy was carried out and these patients were included group 3. Complete blood count, blood serum amylase, and lipase levels were checked before and 12-24 hours after the procedure. The patients were monitored for 30 days for the development of any complications.\nResults: Complications were observed in 26 (14%) of 185 patients included in the study. The complications included pancreatitis in 18 (9.7%) patients, cholangitis in six (3.2%) patients, and hemorrhage in two (1.1%) patients. The frequency of complications was 9.2% (7 of 76 patients) in group 1, 9.3% (7 of 75 patients) in group 2, and 35.3% (12 of 34 patients) in group 3, respectively (p<0.05). When a multivariate analysis was applied, two parameters, the difficulty of cannulation (odds ratio: 3.108) and opaque injection into pancreatic duct (odds ratio: 3.220), were correlated with elevated complication rates.\nConclusion: Difficult cannulation and opaque injection into the pancreas are risk factors for complications after ERCP, while the precut technique is safe. Therefore, it is recommended to prefer precut method earlier, instead of insisting on conventional techniques to avoid the risk of complications.